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Diseases of the tooth: the genetic and molecular basis of inherited anomalies affecting the dentition

Identifieur interne : 000164 ( Main/Exploration ); précédent : 000163; suivant : 000165

Diseases of the tooth: the genetic and molecular basis of inherited anomalies affecting the dentition

Auteurs : Martyn T. Cobourne [Royaume-Uni] ; Paul T. Sharpe [Royaume-Uni]

Source :

RBID : ISTEX:5859B258FB7A76D4EB8613A2FC9C5578F88AD8DF

English descriptors

Abstract

In humans, inherited variation in the number, size, and shape of teeth within the dentitions are relatively common, while rarer defects of hard tissue formation, including amelogenesis and dentinogenesis imperfecta, and problems associated with tooth eruption are also seen. In many cases, these anomalies occur in isolation, but they can also present as a feature of numerous well‐characterized developmental syndromes. Complex reiterative signaling between the epithelium and mesenchyme is a feature of normal tooth development in the embryo, occurring from early patterning through morphogenesis, hard tissue formation and during root development. Significant events also occur during postnatal development of the dentition, including hard tissue maturation and tooth eruption. In the last decade, advances in human and mouse genetics have meant that in many cases candidate genes have been identified for these anomalies. These genes have provided a useful platform for developmental biologists, allowing them to begin elucidating how these signals interact to generate a functional dentition and understand the mechanisms underlying many of the anomalies that are seen in human populations. In this article, we review current concepts relating to the developmental biology of tooth number, size, and shape, formation of the dental hard tissues and eruption of the tooth into the oral cavity. We will focus on the molecular mechanisms underlying these processes in both health and disease. WIREs Dev Biol 2013, 2:183–212. doi: 10.1002/wdev.66 For further resources related to this article, please visit the WIREs website. Conflict of interest: The authors declare that they have no potential sources of conflict of interest with regard to the contents of this article.

Url:
DOI: 10.1002/wdev.66


Affiliations:


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<term>Abnormality</term>
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<term>Agenesis</term>
<term>Aldred</term>
<term>Alveolar bone</term>
<term>Ameloblast</term>
<term>Amelogenesis</term>
<term>Amelogenesis imperfecta</term>
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<term>Anomaly</term>
<term>Autosomal</term>
<term>Autosomal recessive</term>
<term>Axin2</term>
<term>Biol</term>
<term>Biol chem</term>
<term>Biology diseases</term>
<term>Bmp4</term>
<term>Candidate genes</term>
<term>Canine</term>
<term>Cementum</term>
<term>Chromosome</term>
<term>Cleidocranial</term>
<term>Cleidocranial dysplasia</term>
<term>Clinical features</term>
<term>College london</term>
<term>Colorectal</term>
<term>Coronal</term>
<term>Cusp</term>
<term>Cuspal</term>
<term>Defect</term>
<term>Deletion</term>
<term>Dent</term>
<term>Dental anomalies</term>
<term>Dental follicle</term>
<term>Dental lamina</term>
<term>Dental papilla</term>
<term>Dentin</term>
<term>Dentin phosphoprotein</term>
<term>Dentin sialoprotein</term>
<term>Dentine</term>
<term>Dentine dysplasia</term>
<term>Dentinogenesis</term>
<term>Dentinogenesis imperfecta</term>
<term>Dentinogenesis imperfecta type</term>
<term>Dentition</term>
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<term>Dspp</term>
<term>Dysplasia</term>
<term>Ectodermal</term>
<term>Ectodermal dysplasias</term>
<term>Edar</term>
<term>Enam</term>
<term>Enamel</term>
<term>Enamel defects</term>
<term>Enamel formation</term>
<term>Enamel hypoplasia</term>
<term>Enamel knot</term>
<term>Encodes</term>
<term>Epithelial</term>
<term>Epithelium</term>
<term>Eruption</term>
<term>Fgf3</term>
<term>Follicle</term>
<term>Gene</term>
<term>Generalized enamel hypoplasia</term>
<term>Genet</term>
<term>Genetics</term>
<term>Germ</term>
<term>Hard tissue formation</term>
<term>Homeobox</term>
<term>Homeodomain</term>
<term>Human dentition</term>
<term>Human populations</term>
<term>Hypodontia</term>
<term>Hypoplasia</term>
<term>Hypoplastic</term>
<term>Imperfecta</term>
<term>Important role</term>
<term>Incisor</term>
<term>Jernvall</term>
<term>Light polypeptide gene enhancer</term>
<term>Localized</term>
<term>Maas</term>
<term>Mandibular</term>
<term>Matrix</term>
<term>Maxillary</term>
<term>Mesenchyme</term>
<term>Microdontia</term>
<term>Mike harrison</term>
<term>Mineralization</term>
<term>Mineralized</term>
<term>Molar</term>
<term>Molecular basis</term>
<term>Molecular genetics</term>
<term>Molecular mechanisms</term>
<term>Morphogenesis</term>
<term>Morphology</term>
<term>Mouse</term>
<term>Mouse tooth</term>
<term>Msx1</term>
<term>Multiple supernumerary teeth</term>
<term>Murine</term>
<term>Murine tooth development</term>
<term>Mutant</term>
<term>Mutation</term>
<term>Natal teeth</term>
<term>Natl</term>
<term>Nonsense mutation</term>
<term>Nonsyndromic</term>
<term>Nonsyndromic sthag</term>
<term>Normal development</term>
<term>Odontogenic</term>
<term>Oligodontia</term>
<term>Oral cavity</term>
<term>Oral pathol</term>
<term>Oral surg</term>
<term>Organic matrix</term>
<term>Osteoblast differentiation</term>
<term>Osteogenesis</term>
<term>Osteogenesis imperfecta</term>
<term>Parathyroid</term>
<term>Parathyroid protein</term>
<term>Pathol</term>
<term>Pathway</term>
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<term>Permanent dentition</term>
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<term>Phosphoprotein</term>
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<term>Polyposis</term>
<term>Premolar</term>
<term>Primary dentition</term>
<term>Primary enamel knot</term>
<term>Primary teeth</term>
<term>Proc</term>
<term>Proc natl acad</term>
<term>Radiol endod</term>
<term>Rare autosomal</term>
<term>Receptor</term>
<term>Recessive</term>
<term>Root development</term>
<term>Root length</term>
<term>Root morphology</term>
<term>Runx2</term>
<term>Secondary dentition</term>
<term>Secondary dentitions</term>
<term>Secondary teeth</term>
<term>Selective tooth agenesis</term>
<term>Shields type</term>
<term>Sostdc1</term>
<term>Sthag</term>
<term>Supernumerary</term>
<term>Supernumerary teeth</term>
<term>Supernumerary tooth formation</term>
<term>Surg</term>
<term>Syndrome</term>
<term>Syndromic</term>
<term>Syndromic conditions</term>
<term>Talon cusp</term>
<term>Taurodontism</term>
<term>Thesleff</term>
<term>Thin layer</term>
<term>Third molars</term>
<term>Tooth</term>
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<term>Tooth germ</term>
<term>Tooth morphogenesis</term>
<term>Tooth number</term>
<term>Tooth shape</term>
<term>Tooth size</term>
<term>Transcription factor</term>
<term>Transcriptional</term>
<term>Transgenic</term>
<term>Transgenic mice</term>
<term>Transgenic overexpression</term>
<term>Tumor necrosis factor</term>
<term>Turner syndrome</term>
<term>Vestigial</term>
<term>Wang</term>
<term>Wiley</term>
<term>Wiley periodicals</term>
<term>Zhang</term>
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<div type="abstract" xml:lang="en">In humans, inherited variation in the number, size, and shape of teeth within the dentitions are relatively common, while rarer defects of hard tissue formation, including amelogenesis and dentinogenesis imperfecta, and problems associated with tooth eruption are also seen. In many cases, these anomalies occur in isolation, but they can also present as a feature of numerous well‐characterized developmental syndromes. Complex reiterative signaling between the epithelium and mesenchyme is a feature of normal tooth development in the embryo, occurring from early patterning through morphogenesis, hard tissue formation and during root development. Significant events also occur during postnatal development of the dentition, including hard tissue maturation and tooth eruption. In the last decade, advances in human and mouse genetics have meant that in many cases candidate genes have been identified for these anomalies. These genes have provided a useful platform for developmental biologists, allowing them to begin elucidating how these signals interact to generate a functional dentition and understand the mechanisms underlying many of the anomalies that are seen in human populations. In this article, we review current concepts relating to the developmental biology of tooth number, size, and shape, formation of the dental hard tissues and eruption of the tooth into the oral cavity. We will focus on the molecular mechanisms underlying these processes in both health and disease. WIREs Dev Biol 2013, 2:183–212. doi: 10.1002/wdev.66 For further resources related to this article, please visit the WIREs website. Conflict of interest: The authors declare that they have no potential sources of conflict of interest with regard to the contents of this article.</div>
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